| Rotten Tomatoes | São Francisco | 19 de agosto de 1998 |
| RSA Data Security | Bedford | 1986 |
| S&P Global | Rockefeller Center, Nova Iorque | — |
| Saatchi & Saatchi | Nova Iorque | 1970 |
| Safeway | Pleasanton | 1915 |
| Saks Fifth Avenue | Nova Iorque | 1898 |
| Sanmina-SCI | São José | 1980 |
| Santa Cruz Operation | Santa Cruz | 1979 |
| Saucony | Lexington | 1898 |
| Schlumberger | Houston | 1926 |
| Schweizer Aircraft Corporation | Horseheads, Nova Iorque | 1939 |
| Schwinn | Chicago | 1895 |
| SDI Media Group | Culver City | 1965 |
| Sealy Corporation | Trinity | 1881 |
| Sears | Hoffman Estates | 1892 |
| Seattle's Best Coffee | Seattle | 1991 |
| Sharpie | Oak Brook | 1964 |
| Shen Yun | Deerpark | 2006 |
| Sheraton Hotels & Resorts | White Plains | 1937 |
| Shield AI | San Diego | 28 de maio de 2015 |
| Shiny Entertainment | Laguna Beach, Newport Beach | 1993 |
| Showtime | Nova Iorque | 1983 |
| Shure | Niles | 1925 |
| Sierra Nevada Corporation | Sparks | 1963 |
| Silicon Graphics | Sunnyvale, Mountain View | 9 de novembro de 1981 |
| Silicon Laboratories | Austin | 1996 |
| Silver Lake | Menlo Park | 1999 |
| Silvergate Capital | La Jolla | 1988 |
| Sirius Satellite Radio | Nova Iorque | 17 de maio de 1990 |
| Sirius XM Radio | Nova Iorque | 29 de julho de 2008 |
| Six Flags | Arlington | 1961 |
| Skullcandy | Park City | 2003 |
| Skybound Entertainment | Beverly Hills | 1992 |
| Skydance Media | Hollywood | 2006 |
| Skywalker Sound | Lucas Valley | 1975 |
| Smith & Wesson | Springfield | 1852 |
| Snap Inc. | Santa Mônica, Venice | 16 de setembro de 2011 |
| Snap-on | Kenosha | 1920 |
| Sociedade de Criação de Língua | Garden Grove | 2007 |
| Sony Corporation of America | Sony Building, Nova Iorque | 1960 |
| Sony Imagesoft | Los Angeles | 1989 |
| Southern Company | Atlanta | 1945 |
| Southern Pacific Railroad | São Francisco | 1865 |
| SpaceX | Starbase | 14 de março de 2002 |
| SpaceXAI | Área da baía de São Francisco | 9 de março de 2023 |
| Spector | Saugerties | 1976 |
| Spectravideo | — | 1981 |
| Speedway Motorsports | Concord | 1959 |