| Springfield Armory | Geneseo | 1974 |
| Sprint Nextel | Overland Park | 1899 |
| SRI International | Menlo Park | 1946 |
| Standard Oil Company | Ohio, Cleveland, Nova Iorque | 1890 |
| Standard Oil of Ohio | Cleveland | 1911 |
| Stanley Black & Decker | New Britain | 1843 |
| Staples Inc. | Framingham | 1986 |
| State Street Corporation | Boston | 1792 |
| Stepan Company | Northfield | 1932 |
| Stratolaunch Systems | Montgomery, Seattle | 2011 |
| Stripe | São Francisco, South San Francisco | 2010 |
| Studebaker | South Bend | 1852 |
| StumbleUpon | São Francisco | 2001 |
| Stüssy, Inc. | Irvine | 1980 |
| Substack | — | 29 de novembro de 2017 |
| Sun Microsystems | Santa Clara | 24 de fevereiro de 1982 |
| SunPower | São José | 1985 |
| Swift Engineering | San Clemente | 1983 |
| Synaptics | Santa Clara | 1986 |
| Synopsys | Mountain View | 1986 |
| Sysco | Houston | 1969 |
| T-Mobile US | Bellevue | 2001 |
| T. Rowe Price | Baltimore | 1937 |
| Tandem Computers | Cupertino | 1974 |
| TASCAM | Tóquio | 1971 |
| TaylorMade Golf Company | Carlsbad | 1979 |
| Tazo | Portland | 1994 |
| TBWA Worldwide | Nova Iorque | 1970 |
| TD Ameritrade | Omaha | 1971 |
| Teledyne Technologies | Thousand Oaks | 1960 |
| Tenneco | Lake Forest | 1930 |
| TerraPower | Bellevue | 2008 |
| Tesoro Corporation | — | 1968 |
| Texaco | San Ramon | 1901 |
| The Babylon Bee | Jupiter | 1 de março de 2016 |
| The Behemoth | San Diego | 2003 |
| The Boring Company | Hawthorne | 17 de dezembro de 2016 |
| The Earth Institute | Nova Iorque | 1995 |
| The Hartford | Hartford, Connecticut | 1810 |
| The Kennedy/Marshall Company | Santa Mônica | 1992 |
| The Leading Hotels of the World | Nova Iorque | 1928 |
| The Mosaic Company | Plymouth | 2004 |
| The NPD Group | Port Washington | 1967 |
| The Trump Organization | Trump Tower | 1923 |
| The Viper Room | Califórnia | 1993 |
| The Walt Disney Company | Burbank | 16 de outubro de 1923 |
| Thermo Fisher Scientific | Waltham | 2006 |
| Thinking Machines Corporation | Carter's Ink Building | 1983 |